• Active ingredient: Testosterone isocaproate 60 mg, Testosterone phenylpropionate 60 mg, Testosterone propionate/ml 30 mg, Testosterone decanoate 100 mg/ml
• Type: Anabolic steroid (derived from testosterone)
• Form: Injections
• Carrier oil: sesame oil + MCT
  

Description

Testosterone is the primary sex hormone in humans and plays a key role in the development of male reproductive tissues, such as the testes and prostate, and female reproductive tissues, as well as promoting secondary sexual characteristics, such as increased muscle and bone mass and body hair in men. Furthermore, testosterone is involved in health and well-being and the prevention of osteoporosis in both sexes. Insufficient testosterone levels in men can lead to abnormalities, including bone fragility and loss. Testosterone has pronounced anabolic properties: it increases muscle mass, accelerates protein synthesis, increases recovery rate and muscle glycogen supply, etc. Testosterone controls an infinite number of processes in the body, being the most abundant hormone in our body and always necessary, as testosterone medications are used by both elderly individuals with hypogonadism and athletes on steroid cycles.

Mechanism of action

Testosterone binds to androgen receptors and is a precursor to another biologically active androgen, dihydrotestosterone, formed by testosterone's exposure to the enzyme 5α-reduction. Dihydrotestosterone has a fivefold greater ability to bind to androgen receptors. Under the influence of these hormones, the receptor changes its structure and transmits a signal to the cell nucleus, where androgenic effects are realized by altering the activity of certain DNA genes. Testosterone can be converted to estrogen under the influence of aromatase (this characteristic is called aromatization). Predominantly, estrogens, rather than testosterone, activate feedback through the hypothalamic-pituitary-testis axis and suppress endogenous testosterone secretion when exogenous drugs are administered.

Medical Use

Testosterone is included on the World Health Organization's list of essential medicines, which are the most important medications needed in a basic health system. Therefore, the idea that it serves only as an anabolic steroid for muscle growth and strengthening is mistaken. It is a vital hormonal medication. Testosterone is used as a medication to treat gender dysphoria, male hypogonadism, and certain types of breast cancer.

Because testosterone levels decline with age, hormone replacement therapy (HRT) or testosterone replacement therapy (TRT) is necessary to maintain health and quality of life. HRT maintains serum testosterone levels within a normal range. The decline in testosterone production with age has sparked interest in androgen replacement therapy.

Mood, spatial ability, attention, memory, and other important cognitive functions are affected by testosterone in humans. Preliminary evidence suggests that low testosterone levels are a risk factor for cognitive decline and possibly Alzheimer's-type dementia.

In both sexes, testosterone is involved in health and well-being, as well as in the prevention of osteoporosis. Insufficient testosterone levels in men can lead to abnormalities, including bone fragility and loss. Testosterone treatment is also beneficial in adult men with age-related low testosterone levels and who experience sexual dysfunction.

Testosterone for seniors

Men over 35 who complain of malaise are often advised to have their testosterone levels tested, and if it's below 12 nmol/L, they're offered hormone replacement therapy. This decision has several positive aspects. Body composition improves: more lean muscle, less fat, sexual function experiences a second youthfulness, a certain rejuvenating effect, and, in general, the body recovers from all the negative effects it received during the period of androgen deficiency.

Physician's attention is required: It is necessary to constantly monitor the lipid profile, general clinical blood parameters, estradiol and prolactin levels.

It's equally important that natural gonadotropin production during HRT approaches zero. Therefore, if children are to be conceived, special gonadotropin therapy is required.

To select the dosage for testosterone therapy, a doctor's consultation is necessary. Dosage depends on your normal testosterone levels, current levels, body weight, body fat percentage, SHBG, and aromatization process.

Approximate dosages for replacement therapy are much lower than those for athletes, 50 to 200 mg per week.

Testosterone in sports

The main benefit of testosterone is increased muscle mass and strength. In addition to its anabolic effect, the drug has a strong androgenic effect. Androgens act by entering the cell and coming into contact with the AR protein. This contact stimulates the AR protein to change shape and activate. Although it's a small change, the effect is significant because it allows the AR to enter the nucleus and bind to DNA (also known as DNA binding).

Rapid weight gain is associated with significant fluid retention due to sodium retention and estrogenic effects. This is why testosterone often helps treat joint problems, pain, and clicking in the shoulders and knees, but nandrolone and growth hormone would be more appropriate in this regard. Testosterone stimulates the body's regeneration processes. It increases overall tone and the desire to exercise, preventing overtraining. It increases blood oxygenation capacity and nitric oxide production, which leads to a good pump during training.

The recommended dose for sports is 250 to 500 mg per week, while as the athlete's body weight increases, the dosage is often revised upwards. Typically, a testosterone cycle lasts 8 to 10 weeks, with post-cycle therapy performed after 2 to 3 weeks. Testosterone is often used for longer periods. The maximum testosterone dosage is 2,000 mg per week for high-level professional athletes; further increases in dosage are futile; the only thing that will increase are side effects.

To avoid the development of estrogenic side effects due to the aromatization process, it is highly recommended to perform tests, etc., and to determine the need for aromatase inhibitors. It is ideal to test estradiol levels before and during the use of aromatase inhibitors to monitor their effectiveness and determine the necessary dosage. We strongly recommend that you only entrust dosage selection to professionals; however, the information below is provided for reference only.

Testosterone blend

Each form of testosterone in the testosterone blend has a different absorption rate, allowing it to maintain consistently high blood levels of anabolic hormones for nearly a month. There's no need for frequent injections; the testosterone blend is administered only once every three weeks (for medicinal purposes). For muscle-building purposes, more frequent injections are required—once every seven days. Some athletes believe that the testosterone blend is a combined treatment in a single vial, but this is not entirely true, as each component of the medication is converted in the body into a single substance: testosterone.

Dosages

• Beginner: 250 mg per week
• Average dosage: 300-750 mg per week
• High dosage: 750+ mg per week

Effects

• Increased muscle mass
• Testosterone is involved in the development of male genitals, secondary sexual characteristics: deep voice, masculine facial features, male-pattern hair growth, and so on.
• Provides spermatogenesis and male behavior (sexual, aggressiveness, decisiveness)
• Increased muscle mass
• Fat burning
• Increase in strength indicators
• Increase libido
• Reduction of blood cholesterol levels
• Reducing the risk of cardiac ischemia and coronary heart disease
• Stimulation of erythropoiesis and distribution of subcutaneous adipose tissue similar to that of men;
• Influences nitrogen and phosphorus metabolism

Side effects

• Increased blood pressure
• Increased sexual behavior
• Hemoconcentration (blood clotting)
• Possibility of blood clots in arterial and venous vessels
• Water accumulation (edema)
• Masculinization
• Aggression, agitation, irritability
• Alopecia (baldness of the scalp)
• Acne (acne)
• Insomnia (rare)

Profile

• Half-life: 7-15 days
• Frequency of injections: 4-7 days
  

Pharmaceutical form

Injectable oily solution for intramuscular injection.

Contraindications

• Pregnancy
• Known or suspected prostate or breast carcinoma.
• Breast-feeding
• Hypersensitivity to the active substance or to any of the excipients

How to store

• Do not use after expiration date.
• Store between 8º and 30ºC
• Do not freeze
• Protect from light