Clomiphene is a synthetic medication classified as a selective estrogen receptor modulator (SERM). Its active ingredient is clomiphene citrate. The medication was developed in the early 1960s as a popular reproductive medication. It has demonstrated high efficacy in the treatment of female infertility. It is a non-steroidal agent that exerts its effects by interacting with estrogen receptors in the hypothalamus, thereby influencing the hypothalamic-pituitary-gonadal (HPG) axis. According to its chemical structure, clomiphene citrate includes two isomers, zuclomiphene and enclomiphene, which contribute to its pharmacological effects.

In addition to its primary medical applications, the chemical compound has attracted the attention of sports enthusiasts and athletes. In the bodybuilding community, the drug is used off-label in post-cycle therapy (PCT). PCT is a regimen that bodybuilders and athletes begin after regular cycles. These periods are used to restore the rhythm of natural testosterone synthesis and eliminate the adverse effects of anabolic steroid withdrawal. The ingredient is capable of increasing gonadotropin release and, consequently, increasing testosterone levels, making it a valuable tool in this regard. However, despite its widespread use, please note that off-label use of the chemical compound for PCT carries a certain level of risk, and medical supervision is strongly recommended.

Main effects and benefits

Clomilad has several pharmacological effects. It has beneficial effects in both approved and unapproved uses. The main effects and benefits can be categorized as follows.

Increased gonadotropin release

Clomiphene citrate acts as a competitive agent that neutralizes estrogen receptors in the hypothalamus. It blocks estrogen's negative response to the secretion of gonadotropin-releasing hormone (GnRH). Under the action of this chemical, the anterior pituitary gland begins to release more follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This hormonal surge is essential for stimulating ovarian follicle development in women and Leydig cell activation in men.

Increased testosterone

Considering the drug's impact on the male body, Clomiphene Citrate can significantly increase serum testosterone levels. Patients suffering from testicular dysfunction use the drug to improve fertility. Furthermore, the drug has a positive effect on patients recovering from anabolic steroid use. By increasing LH levels, the chemical ingredient improves test performance and accelerates testosterone production. This effect not only helps restore normal physiological functions but also ensures stable muscle mass and strength.

Ovulation stimulation

Clomiphene citrate demonstrates high efficacy in stimulating ovulation in women with anovulatory infertility. According to clinical studies, the ingredient is capable of inducing ovulation in approximately 70 to 80% of women. Approximately 30 to 40% of these women subsequently achieve pregnancy. This characteristic makes the medication a first-line treatment for women with polycystic ovary syndrome (PCOS) and other ovulatory disorders.

Spermatogenesis

In addition to its effect on testosterone, the chemical component also influences sperm parameters in men with low sperm count and other forms of male infertility. Increased FSH levels promote spermatogenesis, leading to improved sperm count, motility, and morphology.

In the images, you can see (A) pre- and post-treatment sperm concentration, (B) total motility, (C) sperm morphology, and (D) serum total testosterone levels. The patients are obese men with oligozoospermia and hypogonadism, treated with the drug for male infertility.

Post-Cycle Therapy (PCT) in Bodybuilding

The ingredient is used in PCT to counteract the suppression of endogenous testosterone production caused by anabolic steroid use. The drug affects gonadotropin release, normalizing testosterone levels and eliminating the risk of side effects associated with hypogonadism, such as muscle loss, fatigue, and depression.

Mechanism of Action

The drug's mechanism of action focuses on its ability to modulate estrogen receptors located in the hypothalamus. It acts in both directions, interfering with the normal negative feedback mechanism.

Hypothalamic action

Upon entering the hypothalamus, the ingredient triggers a chain of reactions aimed at binding to estrogen receptors. This action suppresses the action of endogenous estrogen. This blockade helps prevent the production of negative feedback sent as a result of GnRH secretion. This action leads to an increase in the frequency and amplitude of GnRH pulses, which results in improved anterior pituitary function.

Pituitary Action

Increased GnRH pulses stimulate the pituitary gland to secrete higher levels of LH and FSH. These gonadotropins are essential for regulating the secretion of female sex glands. In the female body, FSH is responsible for the development of ovarian follicles, while LH triggers ovulation. Maintaining these high levels increases the chances of a successful pregnancy. In the male body, LH stimulates Leydig cells in the testes to produce testosterone, while FSH aids in spermatogenesis.

Gonadal Action

Increased FSH levels in the ovaries lead to the growth and maturation of ovarian follicles. The subsequent increase in LH levels results in ovulation. In the male body, LH stimulates the synthesis and secretion of testosterone in the testes, while FSH acts on Sertoli cells to promote spermatogenesis.

This dual action of the chemical component affects both the male and female bodies. The ability to affect hormones and sex cells improves fertility and increases the chances of pregnancy.

Uses

Clomiphene citrate is used clinically to improve fertility in both men and women. The drug helps address a wide range of reproductive health issues. However, it is also used off-label. Its main uses include:

Post-Cycle Therapy (PCT) in Bodybuilding

Sports enthusiasts and bodybuilders who use anabolic steroids often suffer from suppressed natural testosterone production. Taking Clomiphene Citrate helps eliminate this suppression and restore normal hormonal balance during PCT. The ingredient helps activate the HPG axis and increases endogenous testosterone levels. Furthermore, it also prevents the adverse effects of low testosterone, such as muscle loss and depression.

Male Hypogonadism

Clomiphene citrate can be used to treat hypogonadism in men. It is a condition characterized by low testosterone levels. It can lead to erectile dysfunction, decreased libido, fatigue, and reduced muscle mass. The chemical component stimulates endogenous testosterone synthesis, increasing LH and FSH levels.

Male infertility

Clomiphene citrate can improve sperm parameters, including count, motility, and morphology, in men suffering from idiopathic oligospermia or other forms of infertility. This effect helps increase the likelihood of pregnancy through natural conception or assisted reproduction techniques.

Infertility treatment in women

Clomiphene citrate is primarily indicated for the treatment of anovulatory infertility. It is prescribed for women with polycystic ovary syndrome (PCOS). PCOS is a common endocrine disorder characterized by irregular menstrual cycles and anovulation. The medication helps create favorable conditions for natural ovulation, significantly increasing the chances of conception.

Secondary uses

The drug has also been tested for the treatment of other conditions, such as gynecomastia in men, and as adjuvant therapy for certain types of breast cancer. Its ability to modulate estrogen receptors makes it a versatile agent in various clinical settings.

Dosage, Administration and Precautions

Clomiphene citrate is administered orally, and the dosage varies depending on the indication and patient-specific factors. Correct dosing is crucial to maximize efficacy and minimize potential adverse effects.

Post-Cycle Therapy (PCT) in Bodybuilding

In the context of PCT, users typically administer Clomiphene Citrate daily. 50 mg per dose for 4 to 6 weeks is a common dosage. The exact dosage and duration of use may vary depending on the patient's history of prior steroid use. Users should also consider their individual hormonal response. Note that the drug is often combined with other agents, such as Tamoxifen , to optimize HPG axis recovery.

Male Hypogonadism

In the treatment of male hypogonadism, the dosage of Clomiphene Citrate can vary considerably. Thus, the administration regimen can range from 25 to 50 mg daily or every other day. This strategy helps stimulate stable testosterone production, regulating efficacy and minimizing the risk of side effects. Blood tests are performed regularly to assess hormone levels and adjust dosage.

Infertility in women

50 mg daily for 5 days is the standard starting dose to stimulate ovulation in women with anovulatory infertility. Note that the dosing cycle should begin on day 5 of the menstrual cycle. If ovulation does not occur, the dosage can be increased to 100 mg daily. 150 mg daily is the maximum recommended dose, as higher doses do not significantly improve ovulation rates but increase the risk of adverse effects.

Precautions

Clomiphene Citrate tablets are contraindicated in patients with liver disease, abnormal uterine bleeding, ovarian cysts, or uncontrolled thyroid or adrenal dysfunction. Women undergoing treatment should be closely monitored for signs of ovarian hyperstimulation syndrome (OHSS). This is a serious complication characterized by enlarged ovaries and fluid accumulation in the abdomen. If visual disturbances are observed, patients should discontinue use of the medication immediately. Regular monitoring of liver function and hormone levels is recommended during treatment.

Side effects

Although the chemical component is generally well tolerated, some side effects are still observed. These side effects can be categorized based on their frequency and severity. Additionally, certain side effects are gender-specific, meaning they affect only men or women.

Common side effects (incidence ≥10%)

1. Hot flashes. About 10 to 20% of patients experience this side effect. The condition is characterized by sudden sensations of heat, often accompanied by sweating and flushing.
2. Abdominal discomfort. Patients experience bloating and pain in the abdominal region. These symptoms are usually mild.
3. Breast tenderness. Patients may experience breast tenderness or swelling. This sensation is usually temporary and disappears when treatment is discontinued.
4. Mood swings. Some patients report mood changes, including irritability and emotional variability.

Less common side effects (incidence 1–10%)

1. Nausea and vomiting. Gastrointestinal disturbances may occur.
2. Headaches. Some patients reported mild to moderate headaches.
3. Visual disturbances. This side effect includes blurred vision, spotting, or flashes of light (scotoma). These symptoms are usually temporary but require medical attention if they persist.

Rare side effects (incidence <1%)

1. Ovarian hyperstimulation syndrome (OHSS). This side effect can only be experienced by women. It's a serious condition characterized by severe abdominal pain, rapid weight gain, and fluid accumulation in the abdomen and chest. It requires immediate medical attention.
2. Thromboembolic events. Blood clots form in the body, which can lead to serious conditions such as deep vein thrombosis or pulmonary embolism.
3. Elevated liver enzymes. Hepatotoxicity may occur, indicated by elevated liver enzyme levels in blood tests. Therefore, regular monitoring is recommended.
4. Gynecomastia in men. This side effect can only be seen in men. The condition involves the development of breast tissue in men, which is associated with increased estrogen levels due to the mechanism of action of Clomiphene Citrate.

Store

1. Temperature. Clomiphene citrate tablets are best stored at room temperature. 20–25°C (68–77°F) is the best temperature to store the medication. Avoid exposing the medication to extreme temperatures (both hot and cold).
2. Protection against light. Do not leave the medication exposed to direct sunlight. Storing the medication in its original packaging protects it from light.
3. Humidity. Choose dry places to store the product. Avoid storing Clomiphene Citrate in humid environments, such as bathrooms, as moisture can affect the stability of the medication.
4. Packaging. Always store Clomiphene Citrate in its original packaging. The original packaging perfectly protects the medication from environmental factors and contamination.
5. Child safety. Keep Clomiphene Citrate out of reach of children and pets.

Why choose us?

The Driada Medical Store is an online pharmacy where customers can buy Clomiphene Citrate and other medications without a prescription. Our high reputation is proven by numerous reviews. You can read them here: https://www.eroids.com/reviews/driadashop.to .

However, we're not just an online store where you can buy Clomiphene Citrate online; we're a trusted platform where customers receive comprehensive medical care. We've created an online community where participants help each other stay healthy.

Our Benefits

1. A wide range of products. Our assortment includes a variety of medications designed to improve physical performance and promote overall health.
2. Laboratory tests. Our products undergo laboratory testing to verify their quality, which you can find on each product page. You can verify each test using a unique laboratory test code.
3. Free consultation. We have a free bot @driadacycleadvice_bat , through which you can contact our consultants, who offer free consultations, help develop treatment cycles and interpret blood test results.
4. Affordable cost. Clomiphene Citrate is priced low and reasonable. Compared to our competitors, we offer affordable, premium-quality products.
5. Delivery guarantee. As per our policy, we reship orders if they are lost en route to customers.
6. Transparency. Each customer can see the conditions under which Driada Medical products are manufactured. We demonstrate our technological equipment, as well as the production process, here. https://vimeo.com/676269567 .

Join our community https://t.me/+jiWFLy8sRxszMmYx on Telegram to share your experience or get professional assistance. Contact our managers to request Clomiphene Citrate and make a purchase.

Frequently asked questions

Do Clomilad tablets provide an accurate dosage of the active ingredients?

Yes, the tablets are dosed at 25 mg. Depending on the dosage needed, patients can take one or more tablets.

Does Clomiphene Citrate 25 mg contain any other active ingredients?

Clomiphene citrate is the main active ingredient. Other components complement it and are used to ensure stability and better absorption of the chemical ingredient.

Can Clomiphene Citrate be taken without water?

It is recommended to take the tablets with water for better absorption.